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129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder

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129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder

China 129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder supplier
129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder supplier 129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder supplier 129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder supplier

Large Image :  129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder

Product Details:

Place of Origin: HongKong
Brand Name: Hongxi Pharm
Certification: SGS
Model Number: Pharmaceutical Material

Payment & Shipping Terms:

Minimum Order Quantity: 1KG
Price: Negotiable
Packaging Details: Disguise Package
Delivery Time: 5-7 business days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: Adequate Stock
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Detailed Product Description
Name: Fulvestrant Purity: 99%+ USP/BP Grade
MOQ: Powder 1KG Shipping: DHL, UPS, EMS, FEDEX, Post, ECommerce
Package: 25KG Secure/Discreet Shippment Payment: Bitcoin, Western Union, MoneyGram, Bank Transfer

CAS 129453-61-8 Anti-cancer Fulvestrant Faslodex Fulvestrant Acetate Powder with Factory Price

Dear Customers, we also make USP standard Fulvestrant powder which is a little more expensive than enterprise standard Fulvestrant.

 

Fulvestrant/Faslodex Details:
Fulvestrant Faslodex CAS129453-61-8
Fulvestrant Synonyms: Faslodex
Fulvestrant Chemical Name: (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

Fulvestrant CAS:129453-61-8
Fulvestrant Molecular Fomular:C32H47F5O3S
Fulvestrant Molecular Weight:606.77
Fulvestrant Density: 1.201 g/cm3

Fulvestrant Melting Point: 104-106°C

Fulvestrant Boiling Point: 674.8 °C at 760 mmHg

Fulvestrant Appearance: White powder

Fulvestrant Usage: Antineoplastic (hormonal)

 

Fulvestrant/Faslodex Specification:

Fulvestrant Name Fulvestrant
Fulvestrant Alias Faslodex
Fulvestrant CAS 129453-61-8
Fulvestrant MF C32H47F5O3S
Fulvestrant MW 606.77
Fulvestrant Apperance White powder
Fulvestrant Assay 99%
NOTE: Fulvestrant is FDA approved for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti estrogen therapy.


Fulvestrant/Faslodex Description:

(1) Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrante stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cell has.

 

(2) Fulvestrant is a highly selective estrogen receptor antagonist. It exerts its action in the body not by targeting the production of estrogen, but by preventing it from exerting activity on the body. It does this bybinding available estrogen receptors in a competitive manner, making them unavailable for circulating estrogens. This mode of action is very similar to Nolvadex and Clomid, although unlike these two agent fulvestrant does not have mixed agonist/antagonist properties.

 

(3) Fulvestrant is a pure estrogen receptor antagonist. This agent also stands out as the first inject able estrogen antagonist to catch the attention of the athletic and bodybuilding world. Although not widely used here, when applied it may be effective drug for mitigating the side effects of excess estrogen caused by anabolic/androgenic steroid use such as gynecomastia, fat buildup, and increased water retention.

129453-61-8 API Pharmaceutical Materials Fulvestrant Faslodex / Fulvestrant Acetate Powder

(4) Fulvestrante is a selective estrogen receptor down-regulator (SERD). Fulvestrante is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. The dosing schedule for fulvestrante remains under investigation in an attempt to optimize its effectiveness.

 

(5) Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrante stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cell has.

 

(6) The recommended dose is 250mg administered intramuscularly per month as a single 5ml injection or two 2.5ml injections. When used off label to mitigate the estrogenic side effects of anabolic/androgenic steroid use, male athletes and bodybuilders may find a similar dose as is used for medical reasons to be effective for their needs.

 

Fulvestrant/ Faslodex Benefits:

Fulvestrant is administered using intramuscular injections. Faslodex is liquid that is given once a month as an injection into a muscle Fulvestranthas poor oral bioavailability, it comes as a solution (liquid) in the buttockto be administeredvia intramuscular injection. Women usually get Faslodex as long as it is effectively treating the cancer.


Research has shown that Faslodex works as well as or better than Arimidex (chemical name: anastrozole), an aromatase inhibitor, in slowing or stopping the growth of metastatic (breast cancer that has spread to other parts of the body), hormone-receptor-positive breast cancer in postmenopausal women after tamoxifen has stopped working.

 

Fulvestrant/ Faslodex Reference Dosage:

For the most part the full effects of the drug can be achieved using 250 milligrams per injection. Due to the active life of the compound these injections only have to be administered approximately once every four to five weeks. This is obviously a benefit when compared to the frequent dosing schedule that is required with aromatase inhibitors or selective estrogen receptor modulators.

 

At doses of 250 milligrams per month it has been shown that fulvestrant is just as effective as one milligram per day of anastrozole or 2.5 milligrams per day of letrozole at reducing estrogen in the body. It has also been demonstrated in clinical research that fulvestrant can be effective in the treatment of some estrogen-dependent breast cancers where tamoxifen citrate has failed. This should indicate the product is so powerful.

 

Fulvestrant/ Faslodex Quality Test Report(COA):

Test Item Specification Results
Appearance A white to off-white crystalline powder White crystalline powder
Identification The retention time of the major peak in the chromatogram of the assay preparation is same as that of the standard preparation obtained in the assay Conform
Any Individual impurity Not more than 0.10% 0.18%
Total impurities Not more than 1.0% 0.44%
Ratio of isomers Fulvestran A 50.0%-60.0% 51.70%
Fulvestran B 40.0%-50.0% 47.86%
Purity >99.0% 99.56%

 

Fulvestrant/ Faslodex & Breast Cancer:

Fulvestrant (trade name Faslodex) which was developed by AstraZeneca isan intramuscular injection drug, and it was approved for marketing by the US Food and Drug Administration in April 2002.Fulvestrantis a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. Fulvestrant is used to treat hormone receptor positive breast cancer (breast cancer that depends on hormones such as estrogen to grow) in women who have experienced menopause (change of life; end of monthly menstrual periods) and whose breast cancer has worsened after they were treated with antiestrogen medications such as tamoxifen (Nolvadex). Fulvestrant is in a class of medications called estrogen receptor antagonists.

 

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